RT Book, Section
A1 Lechler, Terry
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161320594
T1 Growth and Differentiation of the Epidermis
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161320594
RD 2024/09/11
AB Stem  cell–A  progenitor  cells  that  can  both  self-renew  and  give  rise  to  differentiated  progeny  for  an  extended  period  of  time.Niche–The  tissue  microenvironment  in  which  a  stem  cell  resides  that  provides  chemical  and  mechanical  cues  for  the  maintenance  and  regulation  of  the  stem  cell.Transit  amplifying  cell–Quickly  dividing  cells  that  give  rise  to  differentiated  progeny.  They  are  usually  not  long-lived.Basal  cells–The  proliferative  cells  of  the  epidermis  that  form  the  innermost  layer  that  attaches  to  the  basement  membrane.Spinous  cells–The  first  differentiated  layers  of  the  epidermis.  They  are  post-mitotic  and  enriched  in  desmosomes.Granular  cell–Differentiated  cells  of  the  epidermis  that  contain  keratohyalin  granules  that  contain  precursors  for  the  cornified  envelope.  These  cells  form  tight  junctions  that  provide  some  of  the  barrier  activity  of  the  epidermis.Stratum  corneum–The  terminally  differentiated  layers  of  the  superficial  epidermis.  It  is  composed  of  cornified  envelopes,  highly  crosslinked  meshworks  of  protein  cemented  together  by  specialized  lipids  that  provides  a  barrier  to  the  external  environment.Epigenetics–Control  of  gene  expression  by  modifications  in  chromatin,  including  post-translational  modifications  of  DNA  or  histones,  or  chromatin  remodeling.