RT Book, Section
A1 Gudjonsson, Johann E.
A1 Elder, James T.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161323116
T1 Psoriasis
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161323116
RD 2024/04/16
AB AT-A-GLANCEWorldwide  occurrence;  affects  2%  to  3%  of  Americans;  prevalence  ranges  from  0.1%  to  3%  in  various  populations.A  chronic  disorder  with  polygenic  predisposition  combined  with  triggering  environmental  factors  such  as  trauma,  infection,  or  medication.Erythematous  scaly  papules  and  plaques;  pustular  and  erythrodermic  eruptions  occur.Most  common  sites  of  involvement  are  the  scalp,  elbows,  knees,  hands,  feet,  trunk,  and  nails.Psoriatic  arthritis  occurs  in  10%  to  25%  of  patients;  pustular  and  erythrodermic  forms  may  be  associated  with  fever.Pathology  of  fully  developed  lesions  is  characterized  by  uniform  elongation  of  the  rete  ridges,  with  dilated  blood  vessels,  thinning  of  the  suprapapillary  plate,  and  intermittent  parakeratosis.  Epidermal  and  perivascular  dermal  infiltrates  of  lymphocytes,  with  neutrophils  occasionally  in  aggregates  in  the  epidermis.