RT Book, Section
A1 Gruber-Wackernagel, Alexandra
A1 Wolf, Peter
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161327066
T1 Polymorphic Light Eruption
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161327066
RD 2024/04/24
AB AT-A-GLANCEPolymorphic  light  eruption  is  the  most  common  photodermatosis  with  a  female  preponderance  typically  presenting  in  the  spring.Clinical  presentation:  A  pruritic,  erythematous,  symmetrically  distributed,  eruption  of  variable  interindividual  morphology  (in  most  cases  papular)  on  sun-exposed  skin  areas,  within  hours  to  days  of  exposure,  with  full  resolution  in  several  days.Histopathology:  Epidermal  spongiosis  with  a  superficial  and  deep  dermal,  perivascular,  mixed-cell  infiltrate  and  papillary  dermal  edema.Etiology  and  Pathogenesis:  A  resistance  to  ultraviolet  (UV)-induced  immune  suppression  with  subsequent  delayed-type  hypersensitivity  reaction  against  UV-induced  antigen(s).Prevention  and  Therapy:  Responds  to  broad-spectrum  sunscreen  use,  oral  or  topical  steroids,  and  prophylactic  low-dose  immunosuppressive  phototherapy.