RT Book, Section
A1 Payne, Aimee S.
A1 Stanley, John R.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161331416
T1 Pemphigus
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161331416
RD 2024/04/20
AB AT-A-GLANCETwo  major  types:  pemphigus  vulgaris  and  pemphigus  foliaceus.Pemphigus  vulgaris:  erosions  on  mucous  membranes  and  skin;  flaccid  blisters  on  skin.Pemphigus  foliaceus:  crusted,  scaly  skin  lesions.Pemphigus  vulgaris  histology:  suprabasal  acantholysis.Pemphigus  foliaceus  histology:  subcorneal  acantholysis.Autoantigens  are  desmogleins,  transmembrane  desmosomal  adhesion  molecules.Diagnosis  depends  on  histology  showing  intraepidermal  acantholysis,  immunofluorescence  studies  documenting  the  presence  of  cell  surface  autoantibodies,  either  bound  to  patient  skin  or  in  the  serum,  and/or  enzyme-linked  immunosorbent  assay  showing  anti-desmoglein  antibodiesTherapy  includes  topical  and  systemic  corticosteroids,  oral  immunosuppressive  agents,  intravenous  immunoglobulin,  and  rituximab  (anti-CD20  monoclonal  antibody).