RT Book, Section
A1 Culton, Donna A.
A1 Liu, Zhi
A1 Diaz, Luis A.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161331556
T1 Bullous Pemphigoid
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161331556
RD 2024/04/17
AB AT-A-GLANCEBullous  pemphigoid  usually  occurs  in  older  adults.The  yearly  mortality  rate  varies  from  6%  to  40%.Bullous  pemphigoid  consists  of  pruritic  urticarial  plaques  and  tense,  large  blisters.  Oral  mucous  membrane  erosions  occur  in  a  minority  of  patients.Skin  pathology  shows  subepidermal  blisters  with  eosinophils  and  other  inflammatory  cells.Direct  immunofluorescence  (IF)  shows  C3  and  immunoglobulin  (Ig)  G  at  epidermal  basement  membrane  zone  of  perilesional  skin.  Indirect  IF  shows  IgG  anti–basement  membrane  autoantibodies  in  the  serum.The  autoantigens  BP180  and  BP230  are  proteins  of  the  keratinocyte  hemidesmosome,  a  basal  cell–basement  membrane  adhesion  structure.Therapy  includes  topical  and  systemic  corticosteroids  and  immunosuppressives.