RT Book, Section
A1 Darling, Thomas N.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161349343
T1 Tuberous Sclerosis Complex
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161349343
RD 2024/04/24
AB AT-A-GLANCEAutosomal  dominant  syndrome  with  variable  expressivity.Manifested  by  hamartomatous  tumors  in  multiple  organs,  including  brain  (causing  seizures),  eyes,  heart,  kidneys,  lungs,  and  skin.Skin  lesions  occur  in  nearly  all  individuals  and  are  important  for  diagnosis.Skin  lesions  include  hypomelanotic  macules,  “confetti”  lesions,  facial  angiofibromas,  fibrous  cephalic  plaques,  shagreen  patches,  and  ungual  fibromas.Hypomelanotic  macules  appear  at  birth  or  shortly  thereafter  and  are  most  useful  in  early  diagnosis.Although  the  skin  lesions  are  benign,  they  may  require  treatment  because  of  symptoms  or  disfigurement.Skin  lesions  can  be  treated  with  surgery  or  topical  sirolimus.