RT Book, Section A1 Newman, Sabrina A. A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161351033 T1 Cutaneous Changes in Arterial, Venous, and Lymphatic Dysfunction T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK dermatology.mhmedical.com/content.aspx?aid=1161351033 RD 2024/03/28 AB AT-A-GLANCEMost commonly caused by atherosclerosis of the vessels supplying the lower extremity.Affects 15% of the U.S. adult population older than age 65 years.Stenosis or obstruction of the large arteries to the lower extremities leading to supply–demand mismatch, initially with exertion, but may progress to occur at rest.Intermittent claudication with exertional muscle pain or fatigue, critical limb ischemia with rest pain or tissue compromise, and acute limb ischemia.Cutaneous findings from hypoperfusion range from dry skin, hair loss, and malformed toenails to ulceration and gangrene.