RT Book, Section
A1 DiGiovanna, John J.
A1 Rünger, Thomas M.
A1 Kraemer, Kenneth H.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161339258
T1 Hereditary Disorders of Genome Instability and DNA Repair
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161339258
RD 2024/04/25
AB AT-A-GLANCEGenome  instability  characterizes  a  large  group  of  inherited  disorders  with  prominent  cutaneous  abnormalities;  many  have  an  increased  cancer  risk.Genome  instability  is  caused  by  impaired  repair  and/or  maintenance  of  DNA.Xeroderma  pigmentosum  is  a  prototype  with  impaired  repair  of  environmentally  induced  DNA  damage  and  a  greatly  increased  frequency  of  sunlight-induced  cancer.Although  these  disorders  are  rare,  heterozygous  carriers  of  affected  genes,  which  may  comprise  several  percent  of  the  general  population,  may  carry  an  increased  cancer  risk  as  well.