RT Book, Section
A1 Bravo, Francisco G.
A1 Talhari, Carolina
A1 Ezzedine, Khaled
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161341420
T1 Endemic (Nonvenereal) Treponematoses
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK dermatology.mhmedical.com/content.aspx?aid=1161341420
RD 2024/04/25
AB The  endemic  treponematoses  are  infectious  diseases  caused  by  microorganisms  that  are  closely  related  to  Treponema  pallidum,  the  causative  agent  of  syphilis.  This  group  of  entities  includes  (1)  pinta,  caused  by  Treponema  carateum;  (2)  yaws,  caused  by  T.  pallidum  ssp.  pertenue;  and  (3)  bejel,  caused  by  T.  pallidum  ssp.  endemicum.  Although  all  these  entities  are  caused  by  Treponema  species,  there  are  important  differences  between  the  endemic  treponematoses  and  syphilis,  including  a  nonvenereal  form  of  transmission,  an  endemic  occurrence  in  very  specific  geographic  areas,  a  tendency  to  affect  children  rather  than  sexually  active  adults,  and  a  less  likely  risk  for  congenital  transmission  to  occur.  In  common  with  syphilis,  every  endemic  treponematosis  goes  through  an  early  stage  (including  primary  and  secondary),  a  period  of  latency,  and  a  late  stage.  Significant  morbidity  is  associated  with  progression  of  the  disease,  mainly  affecting  the  skin,  bone,  and  cartilage,  leading  to  significant  disfigurement,  pain,  disability,  and  social  isolation,  causing  more  suffering  to  already  disadvantaged  populations  living  in  poverty.