RT Book, Section A1 Krishna, Sheila M. A1 Garrett, Algin B. A2 Kelly, A. Paul A2 Taylor, Susan C. A2 Lim, Henry W. A2 Serrano, Ana Maria Anido SR Print(0) ID 1161546995 T1 Squamous Cell Carcinoma T2 Taylor and Kelly's Dermatology for Skin of Color, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071805520 LK dermatology.mhmedical.com/content.aspx?aid=1161546995 RD 2024/10/03 AB KEY POINTSPrimary carcinoma of the skin is the most common form of cancer diagnosed in the United States, but the incidence in people with skin of color is reported as rare.Most squamous cell carcinomas (SCCs) in people with skin of color occur in non–sun-exposed areas; however, when SCC does occur in a sun-exposed area, the anatomic distribution is similar to that in Caucasians.SCC that occurs in sun-exposed skin has its origin in loss of the organized control of epidermal keratinocyte differentiation secondary to DNA damage as a direct result of ultraviolet light.The factors that are responsible for developing skin cancers in non–sun-exposed areas are unknown.Areas of chronic inflammation, chronic ulceration, and scarring are predisposed to the development of SCC.