RT Book, Section A1 Yoshida, Yuichi A2 Kelly, A. Paul A2 Taylor, Susan C. A2 Lim, Henry W. A2 Serrano, Ana Maria Anido SR Print(0) ID 1161548982 T1 Neurofibromatosis T2 Taylor and Kelly's Dermatology for Skin of Color, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071805520 LK dermatology.mhmedical.com/content.aspx?aid=1161548982 RD 2024/10/03 AB KEY POINTSNeurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder caused by mutation of the NF1 gene on chromosome 17q11.2, whereas neurofibromatosis type 2 (NF2) is a genetically distinct disorder caused by mutation of the gene on chromosome 22q12.2 encoding merlin.The worldwide prevalence of NF1 is approximately 1 in 3000 individuals with no relation to race.NF1 is characterized by café-au-lait spots, freckling, neurofibromas, Lisch nodules, cerebral tumors, and osseous abnormalities.Clinical manifestations of NF1 are variable in each individual, and the overall degree of severity and complications are not predictable.Patients with NF1 have increased risk of malignancies.Age-specific annual monitoring and treatment of complications by appropriate specialists are important for management of NF1.