RT Book, Section
A1 Jhorar, Preeti
A1 Murphy, Michael
A1 Grant-Kels, Jane M.
A2 Barnhill, Raymond L.
A2 Crowson, A. Neil
A2 Magro, Cynthia M.
A2 Piepkorn, Michael W.
A2 Kutzner, Heinz
A2 Desman, Garrett T.
SR Print(0)
ID 1178387325
T1 Spongiotic Dermatitis
T2 Barnhill's Dermatopathology, 4e
YR 2020
FD 2020
PB McGraw Hill Education
PP New York, NY
SN 9780071828222
LK dermatology.mhmedical.com/content.aspx?aid=1178387325
RD 2023/03/29
AB The  term  “spongiotic  dermatitis”  refers  to  a  large  group  of  inflammatory  disorders  that  share  the  histopathologic  finding  of  spongiosis,  characterized  by  impairment  of  cohesion  between  epidermal  keratinocytes  and  intercellular  edema  (Fig.  2-1  and  Table  2-1).  Spongiosis  is  the  hallmark  of  eczematous  dermatitides  but  can  be  seen  in  a  variety  of  other  skin  conditions  (Table  2-2).  Both  T  lymphocytes  and  keratinocytes  are  thought  to  play  major  roles  in  the  pathogenesis  of  spongiotic  dermatitis.1,2  Skin-infiltrating  T  cells  damage  the  epidermis  by  releasing  pro-inflammatory  cytokines  and  induce  keratinocyte  apoptosis  through  “killer  molecules.”1,2  There  is  subsequent  cleavage  of  adhesion  molecules,  including  E-cadherin,  on  keratinocytes.1,2  Accumulation  of  extracellular  fluid  results  in  widening  of  the  spaces  between  keratinocytes,  causing  the  epidermis  to  resemble  a  sponge  histologically.1,2