RT Book, Section
A1 T. Desman, Garrett
A1 Harvell, Jeff D.
A1 Barnhill, Raymond L.
A2 Barnhill, Raymond L.
A2 Crowson, A. Neil
A2 Magro, Cynthia M.
A2 Piepkorn, Michael W.
A2 Kutzner, Heinz
A2 Desman, Garrett T.
SR Print(0)
ID 1178388658
T1 Nodular and Diffuse Cutaneous Infiltrates
T2 Barnhill's Dermatopathology, 4e
YR 2020
FD 2020
PB McGraw Hill Education
PP New York, NY
SN 9780071828222
LK dermatology.mhmedical.com/content.aspx?aid=1178388658
RD 2023/09/23
AB Nodular  and  diffuse  dermal  cellular  infiltrates  encompass  a  wide  spectrum  of  infectious  and  noninfectious  dermatitides  as  well  as  neoplasms.  Nodular  infiltrates  produce  discrete  cellular  aggregations  that  are  separated  by  relatively  normal  dermis.  Diffuse  infiltrates  tend  to  involve  the  entire  breadth  of  a  biopsy.  They  may  be  relegated  to  either  the  upper,  middle,  or  lower  portion  of  a  specimen  or  can  be  confluent.  Combined  nodular  and  diffuse  patterns  of  infiltration  may  also  be  present  in  some  conditions.  Additionally,  tropism  for  adnexal  structures,  such  as  hair  follicles  and  sweat  ducts  as  well  as  nerve  bundles,  may  characterize  some  diseases.  By  definition,  this  histopathological  category  exhibits  absent  to  minimal  epidermal  involvement.  This  chapter  will  focus  mainly  on  inflammatory  diseases,  dermatoses,  and  some  entities  in  which  the  true  nature  of  the  infiltrate  is  not  precisely  defined  (inflammatory  vs  neoplastic).  Although  many  neoplasms  may  display  these  patterns  (eg,  melanocytic  proliferations,  metastatic  tumors),  they  will  be  treated  mainly  as  differential  diagnoses  that  are  discussed  in  depth  in  other  sections  of  this  book.