RT Book, Section
A1 Crowson, A. Neil
A1 Magro, Cynthia M.
A2 Barnhill, Raymond L.
A2 Crowson, A. Neil
A2 Magro, Cynthia M.
A2 Piepkorn, Michael W.
A2 Kutzner, Heinz
A2 Desman, Garrett T.
SR Print(0)
ID 1178389175
T1 Subepidermal Blistering Diseases
T2 Barnhill's Dermatopathology, 4e
YR 2020
FD 2020
PB McGraw Hill Education
PP New York, NY
SN 9780071828222
LK dermatology.mhmedical.com/content.aspx?aid=1178389175
RD 2024/04/19
AB The  epidermis  binds  to  the  dermis  through  the  basement  membrane  (BM)  zone,  a  complex  network  of  interconnecting  proteins  located  at  the  dermal-epidermal  junction.1,2  Perturbing  the  functions  of  these  proteins,  either  by  mutations3  or  circulating  autoantibodies,4  leads  to  loss  of  tissue  adhesion  and  causes  subepidermal  blistering  diseases.  These  diseases  can  be  classified  into  3  main  groups  (Fig.  8-1  and  Table  8-1)—namely,  autoimmune  subepidermal  blistering  diseases,  subepidermal  blistering  diseases  due  to  mutations  of  proteins  of  the  BM  zone,  and  miscellaneous  subepidermal  blistering  diseases.  To  understand  the  subepidermal  blistering  diseases,  their  histopathology,  and  approach  to  diagnosis,  one  first  requires  a  comprehension  of  the  ultrastructure  and  the  protein  constituents  of  the  basement  membrane  zone.