RT Book, Section
A1 Piepkorn, Michael W.
A2 Barnhill, Raymond L.
A2 Crowson, A. Neil
A2 Magro, Cynthia M.
A2 Piepkorn, Michael W.
A2 Kutzner, Heinz
A2 Desman, Garrett T.
SR Print(0)
ID 1178392319
T1 Alterations of the Stratum Corneum and Epidermis
T2 Barnhill's Dermatopathology, 4e
YR 2020
FD 2020
PB McGraw Hill Education
PP New York, NY
SN 9780071828222
LK dermatology.mhmedical.com/content.aspx?aid=1178392319
RD 2024/04/23
AB An  exceptionally  diverse  group  of  disorders  that  are  both  heterogeneous  in  their  genetic  or  acquired  pathophysiologic  bases  and  pleiotropic  in  their  phenotypic  expressions  can  be  assembled  under  the  general  category  of  alterations  of  the  stratum  corneum  and  epidermis.  These  disorders  reflect  a  wide  range  of  acquired  and  hereditary  pathologic  processes.  Two  distinct  themes,  however,  unite  many  of  the  entities  described  here.  One  common  pathophysiologic  feature  reflects  defects  in  the  cornification  process  that  manifest  clinicopathologically  as  ichthyoses;  the  other  involves  molecular  defects  in  keratin  genes  and  other  genes  yet  to  be  determined  that  confer  defective  epidermal  integrity  and  that  present  clinically  as  the  mechanobullous  disorders.