RT Book, Section A1 Rossi, Anthony M. A1 Lee, Erica H. A1 Nehal, Kishwer S. A2 Avram, Marc R. A2 Avram, Mathew M. A2 Ratner, Désirée SR Print(0) ID 1175090686 T1 Biopsy Techniques T2 Procedural Dermatology YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071795067 LK dermatology.mhmedical.com/content.aspx?aid=1175090686 RD 2024/04/18 AB A skin biopsy is defined as sampling of the integumentary system for histologic evaluation and is a powerful diagnostic tool for the dermatologist. Although a biopsy may seem straightforward, its utility is enhanced when the clinician understands its applications and limitations. As with all diagnostic tools, the pretest probability that a patient will have a specific disease takes into account the prevalence of the disease and the clinical findings. A histological diagnosis should then be clinically correlated with the physician’s differential diagnosis. A skin biopsy is considered the gold standard for the diagnosis of skin lesions and requires that the clinician be familiar with certain key concepts.