RT Book, Section A1 Vejjabhinanta, Voraphol A1 Obagi, Suzan A1 Singh, Anita A1 Baumann, Leslie A2 Baumann, Leslie A2 Saghari, Sogol A2 Weisberg, Edmund SR Print(0) ID 1172445664 T1 Fat and the Subcutaneous Layer T2 Cosmetic Dermatology: Principles and Practice, 2e YR 2009 FD 2009 PB The McGraw-Hill Companies, Inc. PP New York, NY SN 9780071490627 LK dermatology.mhmedical.com/content.aspx?aid=1172445664 RD 2024/04/19 AB Subcutaneous tissue, or the hypodermis, is one of the largest tissues in the human body. The major components of this layer are adipocytes, fibrous tissue, and blood vessels. It is estimated that this layer represents 9% to 18% of body weight in normal-weight men and 14% to 20% in women of normal weight.1 Fat mass can increase up to four fold in severe obesity, which may represent 60% to 70% of total body weight.2 Although gaining fat in the body is undesirable for many, losing fat in the face has cosmetic implications as well. Adipose tissue gain and loss and volume changes contribute to the aged appearance of the face and body. This chapter will review the importance of the subcutaneous tissue and its various functions.