RT Book, Section
A1 Weisberg, Edmund
A1 Baumann, Leslie
A2 Baumann, Leslie
A2 Saghari, Sogol
A2 Weisberg, Edmund
SR Print(0)
ID 1172448312
T1 Fragrance
T2 Cosmetic Dermatology: Principles and Practice, 2e
YR 2009
FD 2009
PB The McGraw-Hill Companies, Inc.
PP New York, NY
SN 9780071490627
LK dermatology.mhmedical.com/content.aspx?aid=1172448312
RD 2023/01/30
AB Innovative  products  and  procedures  inundate  medicine  and  the  specialty  of  dermatology  at  a  dizzying  pace.  At  the  same  time,  the  billion-dollar  beauty  industry  continues  to  expand,  with  few  if  any  signs  of  a  decline.  The  global  fragrance  and  flavor  market  represents  a  significant  and  lucrative  subdivision  of  the  beauty  market  and  is  constantly  testing  various  fragrance  ingredients  to  stay  ahead  of  encroaching  regulation  and  increased  rates  of  sensitization.  Indeed,  while  contact  allergy  to  fragrance  is  not  a  presentation  seen  in  the  dermatologist’s  office  as  frequently  as  acne,  for  example,  it  is  a  common  problem  seen  often  throughout  the  world.  This  is  not  surprising  since  fragrances  are  virtually  omnipresent  in  products  that  come  into  contact  with  the  skin,  for  example,  soaps,  body  lotions  and  moisturizers,  shampoos,  deodorants,  shaving  products,  cosmetics,  perfumes,  sunscreens,  and  dental  products,  as  well  as  food  products,  detergents,  and  even  air  fresheners.  Furthermore,  as  stated  in  Chapter  18,  fragrances  consistently  place  among  the  top  10  contact  dermatitis  allergens  and  represent  the  second  most  common  allergen  family  associated  with  allergic  contact  dermatitis,  second  only  to  nickel,  as  well  as  the  most  often  cited  cause  of  such  reactions  to  cosmetic  products.  This  looms  as  an  especially  important  realization  given  the  general  rise  in  the  incidence  of  contact  allergy  to  various  fragrances  and  the  fact  that  epidemiologic  and  human  allergen  sensitization  studies  have  shown  that  individuals  who  are  found  to  be  sensitive  to  one  allergen  through  patch  testing  are  at  significantly  greater  risk  of  having  a  second  allergen  identified.1–3  Particularly,  given  the  greater  expertise  expected  of  cosmetic  dermatologists  regarding  agents  intended  to  beautify  the  skin,  it  is  incumbent  upon  such  specialists  to  have  a  strong  working  knowledge  of  the  primary  fragrances  identified  as  provoking  allergic  reactions.  This  chapter  will  focus  briefly  on  selected  problematic  fragrances,  primarily  on  the  worst  offenders  found  within  the  Fragrance  Mix  (FM)  I  and  FM  II.