RT Book, Section A1 Aasi, Sumaira A1 Longmire, Michelle A2 Ali, Asra SR Print(0) ID 1176106812 T1 Melanoma and Non-Melanoma Skin Cancer T2 McGraw-Hill Education Specialty Board Review Dermatology: A Pictorial Review, 3e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071793230 LK dermatology.mhmedical.com/content.aspx?aid=1176106812 RD 2024/03/28 AB Negative cancer regulatorsCause apoptosis of DNA-damaged cells and block cell divisionEncode cell-cycle regulators, adhesion molecules, DNA repair enzymes, or signal transduction pathway moleculesp53 most common cancer mutation, present in one-half of all human cancers; ninety percent of squamous cell carcinomas (SCCs) and in most basal cell carcinomas (BCCs) and actinic keratosis (Fig. 12-1)PTCH1 member of the patched gene family that acts as a tumor suppressor in BCC.CDKN2 mutation of this tumor suppressor leads to familial syndrome of pancreatic cancer and melanomaARF functions as a melanoma tumor suppressor by inducing p53-independent senescence