RT Book, Section A1 Lin, Jennifer Y. A1 Lim, Joyce Teng Ee A1 Chan, Henry Hin-Lee A2 Alam, Murad A2 Bhatia, Ashish C. A2 Kundu, Roopal V. A2 Yoo, Simon S. A2 Chan, Henry Hin-Lee SR Print(0) ID 1175119115 T1 Treatment of Melasma T2 Cosmetic Dermatology for Skin of Color YR 2009 FD 2009 PB McGraw Hill Medical PP New York, NY SN 9780071487764 LK dermatology.mhmedical.com/content.aspx?aid=1175119115 RD 2024/03/29 AB Acquired hyperpigmentation disorders of the skin are among the most common complaints in a general dermatology clinic, especially in patients with skin of color. Among those, melasma is known both for causing significant psychosocial stress and for its difficulty to treat. Melasma is classically characterized by symmetric facial hyperpigmented macules and patches commonly affecting the forehead, malar eminences, periorbital areas, and the upper lip. Despite the advent of powerful pigment-targeting lasers, the treatment for melasma remains challenging. This chapter reviews what is currently understood about the pathogenesis, discusses evidence-based treatments, and offers clinical pearls on difficult-to-treat cases.