RT Book, Section
A1 Konstantinov, Nikifor K.
A1 Bigliardi, Paul L.
A2 Soutor, Carol
A2 Hordinsky, Maria K.
SR Print(0)
ID 1190937824
T1 Cutaneous Adverse Drug Reactions
T2 Clinical Dermatology: Diagnosis and Management of Common Disorders, 2e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264257379
LK dermatology.mhmedical.com/content.aspx?aid=1190937824
RD 2024/04/24
AB Adverse  drug  reactions  are  typically  classified  into  type  A  (augmented)  and  B  (bizarre  or  idiosyncratic)  reactions.1  Type  A  reactions  are  often  predictable  and  cause  dose-related  toxicity,  such  as  an  increased  risk  of  bleeding  developing  with  a  supratherapeutic  INR  (international  normalized  ratio)  on  warfarin.  Type  B  reactions,  on  the  other  hand,  are  immune-mediated,  allergic  or  intolerance  reactions  that  often  occur  irrespective  of  the  medication  dose.2  Immune-mediated  reactions  can  be  further  subdivided  into  immediate  (often,  but  not  always  IgE  mediated)  reactions  or  delayed  type,  such  as  T-cell  mediated  reactions  which  can  present  with  a  variety  of  cutaneous  and  systemic  manifestations.3  Immediate  reactions  occur  within  minutes  to  hours  after  medication  exposure  (usually  after  first  exposure)  and  delayed  type  reactions  appear  hours  or  days  after  exposure  to  the  drug.