RT Book, Section
A1 Baumann, Leslie S.
A2 Baumann, Leslie S.
A2 Rieder, Evan A.
A2 Sun, Mary D.
SR Print(0)
ID 1190667226
T1 Intrinsic Aging
T2 Baumann’s Cosmetic Dermatology, 3e
YR 2022
FD 2022
PB McGraw Hill LLC
PP New York, NY
SN 9780071794190
LK dermatology.mhmedical.com/content.aspx?aid=1190667226
RD 2024/04/19
AB SUMMARY  POINTSWhat’s  Important?There  is  much  overlap  between  intrinsic  and  extrinsic  aging.Keratinocyte  and  fibroblast  functions  change  with  aging.Senescent  cells  develop  a  secretory  phenotype  that  accelerates  aging.What’s  New?Emerging  research  is  demonstrating  the  importance  of  the  “tissue  skeleton,”  consisting  of  fibroblasts  and  their  attachments  to  the  ECM  molecules.Lipofuscin  contributes  to  skin  aging  by  reducing  the  activity  of  the  proteasome.Autophagy  decreases  the  rate  of  aging.  Mitochondrial  autophagy  is  especially  important.What’s  Coming?Research  evaluating  the  effects  of  mechanoforces  between  fibroblasts  and  the  ECM  and  ascertaining  how  these  change  with  age.Understanding  the  changes  in  mechanoforces  and  how  they  affect  genetic  expression  and  fibroblast  function.Identifying  epigenetic  methylation  patterns  of  aged  skin.Controlling  macroautophagy  of  mitochondria  may  be  an  anti-aging  strategy  in  the  future.Timely  clearance  of  senescent  cells  before  they  create  too  much  damage  may  be  an  approach  to  prevent  skin  aging.