RT Book, Section A1 Sun, Mary D. A1 Weisberg, Edmund M. A1 Baumann, Leslie S. A2 Baumann, Leslie S. A2 Rieder, Evan A. A2 Sun, Mary D. SR Print(0) ID 1190667643 T1 Nutrition and the Skin T2 Baumann’s Cosmetic Dermatology, 3e YR 2022 FD 2022 PB McGraw Hill LLC PP New York, NY SN 9780071794190 LK dermatology.mhmedical.com/content.aspx?aid=1190667643 RD 2024/03/28 AB SUMMARY POINTSWhat’s Important?Dietary interventions affect skin health and appearance by participating in metabolic processes, mitigating oxidative damage, and/or regulating the expression of cellular components that influence the integrity of skin structure.General recommendations for nutritional therapy include appropriate nutrient supplementation, calorie restriction, limitation of dairy products, and adequate protein intake in older adults. In certain situations, strategies such as intermittent fasting and epigenetic diets can confer benefits to overall health.What’s New?Increases in the activation of mammalian target of rapamycin (mTOR)-1 signaling are significantly associated with acne occurrence and pro-inflammatory states.Acid-rich diets can induce protein catabolism that leads to protein derangement, sometimes described as hypercatabolic protein disarrangement (HPD) syndrome. HPD can manifest with muscle wasting, inflammation, and other symptoms that accelerate aging.What’s Coming?Further research is needed to understand the limitations of foodborne supplements (e.g., storage, bioavailability, solubility) and to develop effective mitigation techniques.Large-scale controlled trials of non-soybean-related isoflavones are warranted in the continued study of nutrition and skin health.