RT Book, Section
A1 Ashrafzadeh, Sepideh
A1 Waldman, Abigail
A2 Nouri, Keyvan
SR Print(0)
ID 1194724030
T1 Cutaneous Squamous Cell Carcinoma
T2 Skin Cancer: A Comprehensive Guide
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260453003
LK dermatology.mhmedical.com/content.aspx?aid=1194724030
RD 2024/04/24
AB SUMMARYSquamous  cell  carcinoma  (SCC)  is  the  malignant  neoplasm  of  keratinocytes.  It  is  the  second  most  common  type  of  skin  cancer  worldwide.The  main  pathogenic  contributors  to  SCC  are  light  skin  pigmentation,  extensive  exposure  to  ultraviolet  (UV)  radiation,  chronic  inflammation  or  scarring,  and  chronic  immunosuppression.Biopsy  facilitates  both  diagnosis  of  SCC  and  identification  of  histopathologic  variants  of  SCC.Treatment  options  for  SCC  are  based  on  tumor  and  patient  characteristics  that  affect  the  risk  of  SCC  recurrence  and  metastasis.  Treatments  for  low-risk  SCC  include  standard  excision,  electrodesiccation  and  curettage,  and  radiation  therapy.  Treatments  for  high-risk  SCC  include  Mohs  micrographic  surgery,  excision  with  complete  margin  assessment,  standard  excision,  radiation  therapy,  and  chemotherapy.Treatment  for  SCC  with  nodal  or  distant  metastases  should  be  formulated  in  multidisciplinary  teams;  management  plans  may  include  surgery,  radiation,  programmed  death-1  (PD-1)  inhibitors,  epidermal  growth  factor  receptor  (EGFR)  inhibitors,  and  systemic  chemotherapy.