RT Book, Section
A1 Samuels, Stuart E.
A1 Freedman, Laura
A1 Wolfson, Aaron H.
A2 Nouri, Keyvan
SR Print(0)
ID 1194728213
T1 Radiation Therapy
T2 Skin Cancer: A Comprehensive Guide
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260453003
LK dermatology.mhmedical.com/content.aspx?aid=1194728213
RD 2024/04/24
AB SUMMARYRadiation  is  an  effective  nonsurgical  therapy  that  provides  long-term  disease  control  and  a  cure  for  squamous  cell  and  basal  cell  skin  cancer.  Typically  used  radiation  modalities  include  low-energy  x-rays,  brachytherapy,  and  electrons  with  a  bolus,  which  target  superficial  skin  and  minimize  doses  to  deeper  normal  tissues.Radiation  can  be  used  for  small  tumors  on  the  face  with  excellent  cosmesis.  Nonsurgical  patients  with  nonmelanoma  skin  cancers  can  also  be  treated  with  radiation.Radiation  is  recommended  as  adjuvant  treatment  in  patients  with  high-risk  features,  such  as  large  tumor  size,  deeply  invasive  disease,  incomplete  excision,  high-grade  lesions,  perineural  invasion,  lymphovascular  invasion,  and  immunosuppression,  as  well  as  cases  of  lymph  node  involvement.The  role  of  radiation  therapy  (RT)  in  melanoma  is  decreasing  because  of  the  increased  use  and  efficacy  of  targeted  agents  and  immunotherapy.  Adjuvant  radiation  should  be  used  for  high-risk  features  such  as  desmoplastic  disease,  bulky  disease,  multiple  lymph  nodes,  and  extracapsular  extension.  Hypofractionation  should  be  considered,  depending  on  the  site  of  disease.Radiation  also  has  a  role  in  the  management  of  Merkel  cell  carcinoma,  primary  cutaneous  lymphoma,  cutaneous  angiosarcoma,  Kaposi  sarcoma,  and  extramammary  Paget  disease.