RT Book, Section
A1 Masciarella, Andrew D.
A1 Tang, Jennifer C.
A2 Nouri, Keyvan
SR Print(0)
ID 1194728415
T1 Topical 5-Fluorouracil
T2 Skin Cancer: A Comprehensive Guide
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781260453003
LK dermatology.mhmedical.com/content.aspx?aid=1194728415
RD 2024/04/25
AB SUMMARYThe  antimetabolites  of  5-FU  disrupt  cell  functioning  through  inhibiting  nucleotide  creation  and  incorporation  into  DNA  and  RNA.5-FU  is  indicated  for  treating  actinic  keratosis  and  superficial  basal  cell  carcinoma.5-FU  has  been  used  as  off-label  treatment  for  squamous  cell  carcinoma  in  situ,  actinic  chelitis,  keratoacanthomas,  among  others.1%,  2%,  and  5%  preparations  typically  follow  a  once-  or  twice-daily  application,  while  0.5%  cream  follows  a  once-daily  application  for  a  duration  dependent  on  the  indication,  anatomic  location,  and  patient  sensitivity  to  treatment.