RT Book, Section A1 Gutierrez, Daniel A2 Baumann, Leslie S. A2 Rieder, Evan A. A2 Sun, Mary D. SR Print(0) ID 1197533953 T1 Skin Pigmentation Disorders T2 Baumann’s Cosmetic Dermatology, 3e YR 2022 FD 2022 PB McGraw Hill LLC PP New York, NY SN 9780071794190 LK dermatology.mhmedical.com/content.aspx?aid=1197533953 RD 2024/03/28 AB SUMMARY POINTSWhat’s ImportantDisorders of pigmentation are commonly seen, can cause significant distress, and often require a multi-modal approach in order to provide satisfactory outcomes.Dyspigmentation is often multifactorial and can stem from a combination of both environmental (photo-induced) and intrinsic (constitutional skin pigmentation) factors.The melanin biosynthesis pathway is complex and improved knowledge regarding these mechanisms may yield additional targets for therapy in the future.What’s NewThe effect of light outside of the ultraviolet spectrum is becoming better elucidated. Visible light is able to illicit dyspigmentation in darker-skin individuals. Therefore, it is crucial to protect against the visible light spectrum when counseling patients on management of their pigmentary disorders.For treatment of melasma, new skin-lightening options are becoming available and being integrated into clinical practice. These include methimazole, flutamide, cysteamine, and tranexamic acid.What’s ComingNewer protocols for treatment of dyschromia are continually being developed as technology advances. Picosecond lasers represent one of the newer advances in treatment of melasma. Best practices for integration of these devices in clinical practice are currently underway.Larger studies in diverse populations comparing medical and procedural interventions are occurring to determine the optimal combination of interventions for treatment of various dyschromia.