RT Book, Section A1 Sun, Mary D. A1 Weisberg, Edmund M. A1 Baumann, Leslie S. A2 Baumann, Leslie S. A2 Rieder, Evan A. A2 Sun, Mary D. SR Print(0) ID 1197533994 T1 Wrinkled Skin T2 Baumann’s Cosmetic Dermatology, 3e YR 2022 FD 2022 PB McGraw Hill LLC PP New York, NY SN 9780071794190 LK dermatology.mhmedical.com/content.aspx?aid=1197533994 RD 2024/04/24 AB SUMMARY POINTSWhat’s Important?Facial wrinkles are a common, yet frequently distressing, consequence of physiological aging processes.Wrinkles are most commonly treated with injections of botulinum neurotoxin type A, which are commercially available in multiple preparations. These treatments are now the most frequently performed cosmetic procedures in the United States.What’s New?Soft tissue fillers, also delivered via facial injection, have become increasingly popular for midface augmentation and the treatment of facial wrinkles.New evidence supports the potential efficacy of topical products containing antioxidants, peptides, and various growth factors in treating skin aging.What’s Coming?Additional research is needed to determine the effects of multiple treatment cycles, frequency of significant adverse events, and duration of the effects of botulinum neurotoxin injections.Future treatment mechanisms may result from an improved understanding of the mechanisms underlying age-related changes to neuroendocrine pathways, thyroid function regulation, and lipid metabolism.